Josh Siegle
Scalable systems neuroscience
My work pushes the limits of large-scale neural recording, produces widely used open datasets and software, and has revealed fundamental links between brain anatomy and spiking dynamics.
Positions
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Senior Scientist, Allen Institute for Neural Dynamics (2021-present)
Leader of the Electrophysiology Group -
Assistant Investigator, Allen Institute MindScope Program (2020-2021)
Collected and shared massive open datasets of spiking activity from the mouse visual system -
Scientist I & II, Allen Institute MindScope Program (2014-2020)
Early adopter of Neuropixels probes for in vivo electrophysiology
Education
- PhD, Neuroscience, Massachusetts Institute of Technology (2014)
- ScB, Neuroscience, Brown University (2007)
Selected Publications
- Lakunina A, Socha KZ, Ladd A, […] Siegle JH, Carandini M (2025) “Neuropixels Opto: Combining high-resolution electrophysiology and optogenetics” bioRxiv.
- De Vries SEJ, Siegle JH, Koch C (2023) “Sharing neurophysiology data from the Allen Brain Observatory.” eLife 12, e85550.
- Siegle JH, Jia X, Durand S, Gale S, Bennett C, Graddis N, Heller G, Ramirez TK, Choi H et al. (2021) “Survey of spiking in the mouse visual system reveals functional hierarchy.” Nature 592, 86-92.
- Jun JJ, Steinmetz NA, Siegle JH, Denman DJ, Bauza M, Barbarits B, Lee AK, et al. (2017) “Fully integrated silicon probes for high-density recording of neural activity.” Nature 551, 232-236.
- Siegle JH, Cuevas López A, Patel Y, Abramov K, Ohayon S, Voigts J (2017) “Open Ephys: An open-source, plugin-based platform for multichannel electrophysiology.” Journal of Neural Engineering 14, 045003.
- Siegle JH, Wilson MA (2014) “Enhancement of encoding and retrieval functions through theta phase-specific manipulation of hippocampus.” eLife 3, e03061.
Awards & Fellowships
- NRSA Fellowship (2012-2014)
- National Defense Science and Engineering Graduate Fellowship (2009-2012)
- Brown University Neuroscience Prize (2007)
Teaching Experience
- Neuropixels and OpenScope Workshop, Organizer (2019-2025)
- MPFI Advanced Neurotechniques Course, Lecturer (2025)
- UCL Neuropixels Workshop, Lecturer (2023-2024)
- Paris Neuro Course, Lecturer (2022-2024)
- Summer Workshop on the Dynamic Brain, Instructor (2023)